Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

AntipsychoticsExample report

Clozapine

Clozaril

Use as directed

Your CYP2D6 result does not change how clozapine should be dosed.

The genes behind this label

The guidelines read one gene for clozapine. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result doesn't change the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

DPWG guideline

Use as directed Evidence: moderateRead the guideline (Dutch Pharmacogenetics Working Group, opens in a new tab)

In plain words: Your CYP2D6 result does not change how clozapine should be dosed.
What it means: CYP2D6 variation can change clozapine blood levels, but this has no clinical consequences.
What the guideline suggests: No action is required. Use standard clozapine dosing.

FDA drug label

Use as directed See the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: Your body may clear this drug faster than average. The FDA label gives no dose change for your result.
What it means: No FDA guidance for this phenotype
What the label suggests: Initiate therapy with recommended starting dose.

About clozapine

Clozapine (Clozaril) is an antipsychotic for schizophrenia that has not responded to other treatments, and for lowering the risk of recurrent suicidal behavior in schizophrenia or schizoaffective disorder.

Used for: Treatment-resistant schizophrenia; reducing the risk of recurrent suicidal behavior in schizophrenia or schizoaffective disorder

Others in antipsychotics

Compare all 12 antipsychotics

And 3 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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