Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

Antidepressants · SSRIsExample report

Vortioxetine

Trintellix, Brintellix

Consider alternative

Your body clears this drug very fast, so it may not work as well. A different antidepressant is often suggested, or a higher dose.

The genes behind this label

The guidelines read one gene for vortioxetine. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

CPIC guideline

Consider alternative Evidence: optionalRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)

In plain words: Your body clears this drug very fast, so it may not work as well. A different antidepressant is often suggested, or a higher dose.
What it means: Increased metabolism of vortioxetine to inactive compounds compared with normal metabolizers. Lower plasma concentrations decrease the probability of clinical benefit.
What the guideline suggests: Select alternative drug not predominantly metabolized by CYP2D6. If vortioxetine use is warranted, initiate therapy at standard starting dose and titrate to maintenance dose based on efficacy and side effects. Increasing the target maintenance dose by 50% or more may be needed for efficacy.

FDA drug label

Use as directed See the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: You may break down this drug faster than usual, but the drug label gives no dose change for your result.
What it means: No FDA guidance for your genotype
What the label suggests: Initiate therapy with recommended starting dose.

About vortioxetine

Vortioxetine (Trintellix) is an antidepressant for major depressive disorder in adults that blocks serotonin reuptake and also acts on several serotonin receptors.

Used for: Major depressive disorder in adults (the FDA-labeled use)

Others in antidepressants

Compare all 14 antidepressants

And 5 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

Back to the example report