Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

Antidepressants · SNRIsExample report

Venlafaxine

Effexor XR

Use as directed

Your body may break down this drug faster than usual, but no dose change is advised.

The genes behind this label

The guidelines read one gene for venlafaxine. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result doesn't change the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

CPIC guideline

Use as directed Read the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)

In plain words: Your body may break down this drug faster than usual, but no dose change is advised.
What it means: Increased metabolism of venlafaxine to the active metabolite O-desmethylvenlafaxine (desvenlafaxine) and increased O-desmethylvenlafaxine:venlafaxine ratio compared with normal metabolizers. There is insufficient evidence supporting the clinical impact of this increased ratio.
What the guideline suggests: No action recommended based on genotype for venlafaxine because of minimal evidence regarding the impact on efficacy or side effects.

FDA drug label

Use as directed See the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: Your body processes venlafaxine faster than most people, but there is no specific FDA guidance for your genotype. The standard dose is typically used.
What it means: No FDA guidance for your genotype
What the label suggests: Initiate therapy with recommended starting dose.

About venlafaxine

Venlafaxine (Effexor XR) is a serotonin and norepinephrine reuptake inhibitor (SNRI) used for depression and three anxiety disorders.

Used for: Major depressive disorder, generalized anxiety disorder, social anxiety disorder and panic disorder in adults

Others in antidepressants

Compare all 14 antidepressants

And 5 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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