Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

Antidepressants · SSRIsExample report

Paroxetine

Paxil, Seroxat

Consider alternative

Your body clears this drug very fast, so it may not work well. A different drug is usually suggested.

The genes behind this label

The guidelines read one gene for paroxetine. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

CPIC guideline

Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)

In plain words: Your body clears this drug very fast, so it may not work well. A different drug is usually suggested.
What it means: Increased metabolism of paroxetine to less active compounds compared with CYP2D6 normal metabolizers. Lower plasma concentrations decrease the probability of clinical benefit.
What the guideline suggests: Select alternative drug not predominantly metabolized by CYP2D6.

About paroxetine

Paroxetine (Paxil) is a selective serotonin reuptake inhibitor (SSRI) used for depression and several anxiety disorders.

Used for: Major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, generalized anxiety disorder and post-traumatic stress disorder in adults

Others in antidepressants

Compare all 14 antidepressants

And 5 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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