CYP2C19Your two copies: *1/*2
Intermediate metabolizer
One copy works and one doesn't.
Handles several SSRIs, acid reducers such as omeprazole, and the blood thinner clopidogrel.
This result changes the label.
Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report
Antidepressants · SSRIsExample report
Sertraline
Zoloft
Use with caution
Your body processes this drug a bit more slowly. You can start at the usual dose, but your doctor may raise it slowly.
The genes behind this label
The guidelines read 2 genes for sertraline. Each card shows the two copies this person inherited and what they mean.
CYP2B6Your two copies: *18+Unknown/*9
Unable to determine
One copy (*9) works less well. The other (*18) also carries a variant that doesn't match any known version of the gene. So we can't say how well CYP2B6 works overall.
Breaks down efavirenz, ketamine, methadone and some drugs for depression.
No clear result for this gene (see above), so its part in the label is unknown.
What the guidelines say
What each guideline says about your result.
CYP2C19Intermediate metabolizerCYP2B6Indeterminate
CPIC guideline, both genes together
Unable to determine Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- We couldn't read the gene this drug depends on, so we can't say how you'll respond.
A combined CYP2C19 + CYP2B6 recommendation could not be given because one of the two genes was not called or has an indeterminate result. See the per-gene detail below.
From the combined CYP2C19 and CYP2B6 table in CPIC's guideline for serotonin reuptake inhibitor antidepressants.
CYP2B6Indeterminate
CPIC guideline
Unable to determine Read the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- The impact of your genotype on response to this drug is unknown.
- What it means
- No CPIC guidance for this phenotype.
- What the guideline suggests
- A genotype-based dosing recommendation cannot be determined from this result.
CYP2C19Intermediate metabolizer
CPIC guideline
Use with caution Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body processes this drug a bit more slowly. You can start at the usual dose, but your doctor may raise it slowly.
- What it means
- Reduced metabolism of sertraline to less active compounds when compared with CYP2C19 normal metabolizers.
- What the guideline suggests
- Initiate therapy with recommended starting dose. Consider a slower titration schedule and lower maintenance dose than CYP2C19 normal metabolizers.
About sertraline
Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI) antidepressant used for depression, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder and premenstrual dysphoric disorder.
- Used for
- Major depressive disorder, obsessive-compulsive disorder (also in children 6 and older), panic disorder, post-traumatic stress disorder, social anxiety disorder, premenstrual dysphoric disorder
Others in antidepressants
Compare all 14 antidepressants- CitalopramCelexa Use with caution
- EscitalopramLexapro Use with caution
- FluvoxamineLuvox Use as directed
- ParoxetinePaxil, Seroxat Consider alternative
- VortioxetineTrintellix, Brintellix Consider alternative
- VenlafaxineEffexor XR Use as directed
- AmitriptylineElavil Consider alternative
- ClomipramineAnafranil Consider alternative
Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.