Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

AntipsychoticsExample report

Risperidone

Risperdal

Use with caution

Your body turns risperidone into its active form faster than usual, and it is more likely not to work well for you. Your doctor may choose a different drug or adjust the dose carefully.

The genes behind this label

The guidelines read one gene for risperidone. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

DPWG guideline

Evidence: moderateRead the guideline (Dutch Pharmacogenetics Working Group, opens in a new tab)

In plain words: Your body turns risperidone into its active form faster than usual, and it is more likely not to work well for you. Your doctor may choose a different drug or adjust the dose carefully.
What it means: Increased CYP2D6 activity raises the ratio of the active metabolite (9-hydroxyrisperidone, or paliperidone) to risperidone. The share of patients with therapy failure rises from 16% to 37%.
What the guideline suggests: Choose an alternative or titrate the dose according to the maximum dose for the active metabolite (paliperidone) (oral 12 mg/day for adults and children from 15 years of age weighing at least 51 kg and 6 mg/day for children from 15 years of age weighing less than 51 kg; intramuscular 75 mg per 2 weeks).

About risperidone

Risperidone (Risperdal) is a second-generation antipsychotic used for schizophrenia, bipolar mania and irritability associated with autism.

Used for: Schizophrenia; manic or mixed episodes of bipolar I disorder; irritability associated with autistic disorder

Others in antipsychotics

Compare all 12 antipsychotics

And 3 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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