Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report

Oncology · ChemotherapiesExample report

Gefitinib

Iressa

Use with caution

Your body breaks down gefitinib more slowly than normal, causing higher levels of the drug in your system. This increases the risk of side effects and closer monitoring may be needed.

The genes behind this label

The guidelines read one gene for gefitinib. Each card shows the two copies this person inherited and what they mean.

CYP2D6*4/*4

Poor metabolizer

Neither copy works.

0.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Poor metabolizer

FDA drug label

See the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: Your body breaks down gefitinib more slowly than normal, causing higher levels of the drug in your system. This increases the risk of side effects and closer monitoring may be needed.
What it means: Results in higher systemic concentrations and higher adverse reaction risk. Monitor for adverse reactions.
What the label suggests: Monitor for adverse reactions.

About gefitinib

Gefitinib (Iressa) is a targeted cancer drug for metastatic non-small cell lung cancer with specific EGFR mutations in the tumor.

Used for: First-line treatment of metastatic non-small cell lung cancer whose tumors have EGFR exon 19 deletions or exon 21 (L858R) mutations

Others in oncology

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And 4 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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