Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report

Oncology · ChemotherapiesExample report

Fluorouracil

Adrucil, Carac

Use as directed

Your body breaks down this drug normally. Your risk of side effects is typical, and the usual dose is used.

The genes behind this label

The guidelines read one gene for fluorouracil. Each card shows the two copies this person inherited and what they mean.

DPYDReference/Reference

Normal metabolizer

Both copies work normally.

2.0 activity scoreTypical: 2

Breaks down the cancer drugs fluorouracil and capecitabine.

This result doesn't change the label.

What the guidelines say

What each guideline says about your result.

DPYDNormal metabolizer (activity score 2.0)

CPIC guideline

Use as directed Evidence: strongRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)

In plain words: Your body breaks down this drug normally. Your risk of side effects is typical, and the usual dose is used.
What it means: Normal DPD activity and “normal” risk for fluoropyrimidine toxicity
What the guideline suggests: Based on genotype, there is no indication to change dose or therapy. Use label-recommended dosage and administration

FDA drug label

Use as directed See the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: Your body processes fluorouracil at a normal rate. The standard dose should work as expected.
What it means: No FDA guidance for your genotype
What the label suggests: Initiate therapy with recommended starting dose.

About fluorouracil

Fluorouracil, often called 5-FU, is an intravenous chemotherapy drug for cancers of the colon and rectum, breast, stomach and pancreas, usually given with other cancer drugs.

Used for: Adenocarcinoma of the colon and rectum, breast, stomach and pancreas, usually as part of a combination regimen

Others in oncology

Compare all 13 oncology

And 4 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

Back to the example report