DPYDYour two copies: Reference/Reference
Normal metabolizer
Both copies work normally.
2.0 activity scoreTypical: 2Breaks down the cancer drugs fluorouracil and capecitabine.
This result doesn't change the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Oncology · ChemotherapiesExample report
Capecitabine
Xeloda, Xitabin, Kapetral
Use as directed
Your body processes capecitabine normally. You have a typical risk of side effects, and the standard dose is expected to be appropriate.
The genes behind this label
The guidelines read one gene for capecitabine. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
DPYDNormal metabolizer (activity score 2.0)
CPIC guideline
Use as directed Evidence: strongRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body processes capecitabine normally. You have a typical risk of side effects, and the standard dose is expected to be appropriate.
- What it means
- Normal DPD activity and “normal” risk for fluoropyrimidine toxicity
- What the guideline suggests
- Based on genotype, there is no indication to change dose or therapy. Use label-recommended dosage and administration
FDA drug label
Use as directed See the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- Your body breaks down capecitabine at a normal rate. The standard dose should work as expected.
- What it means
- No FDA guidance for your genotype
- What the label suggests
- Initiate therapy with recommended starting dose.
About capecitabine
Capecitabine (Xeloda) is a chemotherapy tablet for cancers of the colon and rectum, breast, stomach, esophagus and pancreas.
- Used for
- Cancers of the colon and rectum, breast, stomach, esophagus and gastroesophageal junction, and pancreas, alone or in combination regimens
Others in oncology
Compare all 13 oncologyDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.