CHRNA5Your two copies: rs16969968G/rs16969968G
GGNormal function
A nicotine receptor in the brain linked to heavy smoking.
This result doesn't change the label.
Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report
Other substancesExample report
Nicotine
Cigarettes, Zyn
Use with caution
This result has been studied in relation to smoking, but the findings are mixed. Some studies found people with it did better when quitting with nicotine replacement.
The genes behind this label
The guidelines read 3 genes for nicotine. Each card shows the two copies this person inherited and what they mean.
COMTYour two copies: rs4680A/rs4680A
Decreased function
Both copies work less well.
Breaks down dopamine and other brain chemicals.
This result changes the label.
CYP2A6Your two copies: *1/*17
Intermediate metabolizer
One copy works and one works less well.
Breaks down nicotine.
This result doesn't change the label.
What the guidelines say
What each guideline says about your result.
CHRNA5Normal function
Gene2Rx research summary
Use as directed See the drug page (Gene2Rx research summaries, opens in a new tab)
- In plain words
- Your genes give you a typical risk of becoming hooked on nicotine.
- What it means
- rs16969968 G/G (Asp398/Asp398). No added risk of heavier smoking or delayed cessation from this variant.
- What the research suggests
- Typical response to nicotine. Standard cessation counseling and pharmacotherapy as indicated.
COMTDecreased function
Gene2Rx research summary
Use with caution Evidence: weakSee the drug page (Gene2Rx research summaries, opens in a new tab)
- In plain words
- This result has been studied in relation to smoking, but the findings are mixed. Some studies found people with it did better when quitting with nicotine replacement.
- What it means
- rs4680 Met/Met. Lowest COMT activity (Met is described as having 3 to 4 times lower activity than Val). Some studies associate Met/Met with better quitting on nicotine replacement and others find weak or no association with smoking heaviness or cessation.
- What the research suggests
- No reliable genotype-based change to cessation treatment; standard counseling and pharmacotherapy.
CYP2A6Intermediate metabolizer
Gene2Rx research summary
Use as directed Evidence: moderateSee the drug page (Gene2Rx research summaries, opens in a new tab)
- In plain words
- You clear nicotine a little more slowly than average.
- What it means
- One reduced-function allele. Nicotine clearance is moderately reduced, giving modestly higher and longer-lasting nicotine levels; reduced CYP2A6 function is associated with smoking fewer cigarettes per day.
- What the research suggests
- Nicotine remains in circulation longer; no change to standard cessation treatment is needed on the basis of this result.
About nicotine
Nicotine is the addictive substance in tobacco and the active ingredient in nicotine replacement products used to quit smoking.
Others in other substances
Compare all 7 other substancesDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.