CYP1A2Your two copies: *1/*1
Normal metabolizer
Both copies work normally.
Breaks down caffeine and some medicines, such as clozapine.
This result doesn't change the label.
Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report
Other substancesExample report
Caffeine
Coffee, Tea
Use as directed
Your body clears caffeine at an expected rate. The usual advice on caffeine limits applies.
The genes behind this label
The guidelines read one gene for caffeine. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP1A2Normal metabolizer
Gene2Rx research summary
See the drug page (Gene2Rx research summaries, opens in a new tab)
- In plain words
- Your body clears caffeine at an expected rate. The usual advice on caffeine limits applies.
- What it means
- No rs762551 A allele and no F186L allele (*1/*1), or one of each. Expected caffeine clearance. Note: in the coffee and cardiovascular literature, C/C is classed as a 'slow' metabolizer genotype.
- What the research suggests
- Follow standard moderate intake guidance (up to 400 mg a day for most adults).
Also an ingredient in
Caffeine is also in these combination products. The guidance above is for caffeine on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
- Acetaminophen and caffeineExcedrin Tension Headache, Excedrin Mild Headache, Excedrin Quick Tab, Panadol Extra
- Acetaminophen, aspirin and caffeineExcedrin, Anacin Advanced Headache Formula, Arthriten Inflammatory Pain, Backaid IPF, Pamprin Max Formula, Vanquish
- Acetaminophen, butalbital and caffeineFioricet, Capacet, Esgic, Repan, Vanatol, Vtol, Zebutal
- Acetaminophen, butalbital, caffeine and codeineFioricet with Codeine
- Acetaminophen, caffeine and pyrilamineMidol Complete
- Aspirin and caffeineAnacin, BC Arthritis, BC Original Formula, Stanback Headache Powder
- Aspirin, butalbital and caffeineFiorinal
- Aspirin, butalbital, caffeine and codeineAscomp
About caffeine
Caffeine is cleared almost entirely by one liver enzyme, CYP1A2.
Others in other substances
Compare all 7 other substancesDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.