NAT2Your two copies: *4/*5
Intermediate metabolizer
One copy works faster than usual and one works less well.
Breaks down hydralazine, isoniazid and some other drugs.
This result changes the label.
Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report
Cardiovascular · AntihypertensivesExample report
Hydralazine
Apresoline
Use with caution
Your body breaks down hydralazine somewhat quickly. You will likely need a higher total daily dose to get a good effect.
The genes behind this label
The guidelines read one gene for hydralazine. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
NAT2Intermediate metabolizer
CPIC guideline
Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body breaks down hydralazine somewhat quickly. You will likely need a higher total daily dose to get a good effect.
- What it means
- Predicted to have reduced plasma concentrations and efficacy of hydralazine compared to NAT2 poor metabolizers.
- What the guideline suggests
- Consider a starting total daily dose of at least 75 mg. Titrate up to 300 mg total daily hydralazine dose as tolerated. NAT2 intermediate metabolizers typically require a 50-100% higher maintenance dose compared to poor metabolizers.
Also an ingredient in
Hydralazine is also in these combination products. The guidance above is for hydralazine on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
About hydralazine
Hydralazine is a blood vessel relaxant used mainly for hypertension that has not responded to other medicines, and with isosorbide dinitrate for heart failure.
- Used for
- High blood pressure, especially resistant hypertension; heart failure with isosorbide dinitrate
Others in cardiovascular
Compare all 7 cardiovascularDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.