Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report

Antidepressants · TricyclicsExample report

Nortriptyline

Pamelor

Consider alternative

Your body breaks down this drug very slowly, so it builds up and side effects are more likely. A different drug is usually suggested.

The genes behind this label

The guidelines read one gene for nortriptyline. Each card shows the two copies this person inherited and what they mean.

Poor metabolizer

Neither copy works.

0.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What each guideline says about your result.

CYP2D6Poor metabolizer

CPIC guideline

In plain words: Your body breaks down this drug very slowly, so it builds up and side effects are more likely. A different drug is usually suggested.
What it means: Greatly reduced metabolism of TCAs to less active compounds compared to normal metabolizers. Higher plasma concentrations of active drug will increase the probability of side effects.
What the guideline suggests: Avoid tricyclic use due to potential for side effects. Consider alternative drug not metabolized by CYP2D6. If a TCA is warranted, consider 50% reduction of recommended starting dose. Utilize therapeutic drug monitoring to guide dose adjustments.

Nortriptyline is a tricyclic antidepressant, sold as Pamelor and as a generic, and it is also the active compound the body makes from amitriptyline.

Used for: Depression (the FDA-labeled use). Tricyclics are also used for nerve pain and migraine prevention.

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.