GLP1RYour two copies: rs10305420C/rs10305420C
CCTypical response
The receptor that semaglutide and other GLP-1 drugs act on.
This result doesn't change the label.
Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report
Weight managementExample report
Tirzepatide
Mounjaro, Zepbound
Use as directed
Your genes point to typical weight loss on this drug, with the lowest chance of stomach side effects.
The genes behind this label
The guidelines read 2 genes for tirzepatide. Each card shows the two copies this person inherited and what they mean.
GIPRYour two copies: rs1800437G/rs1800437G
Normal function
Both copies work normally.
A gut-hormone receptor that tirzepatide and retatrutide act on.
This result doesn't change the label.
What the guidelines say
What each guideline says about your result.
GLP1RTypical responseGIPRNormal function
Gene2Rx research summary, both genes together
Evidence: moderateSee the drug page (Gene2Rx research summaries, opens in a new tab)
- In plain words
- Your genes point to typical weight loss on this drug, with the lowest chance of stomach side effects.
- What it means
- GLP1R: the more common Pro7/Pro7 form of the signal peptide (rs10305420 C/C). GIPR: full-function Glu354/Glu354 (rs1800437 G/G). This is the lowest-risk genotype pair: estimated risk of moderate-to-severe vomiting on tirzepatide is about 2.5%, and nausea about 14%. Expected weight-loss efficacy from the GLP1R arm of tirzepatide. GIPR is full-function, so it adds no extra GI risk on tirzepatide.
- What the research suggests
- Standard dosing and titration are expected to produce an average response.
Gene2Rx guideline based on Su et al., Nature (2026), which linked GLP1R rs10305420 and GIPR rs1800437 to nausea and vomiting on tirzepatide. The GIPR effect was specific to tirzepatide and was not seen with semaglutide.
Gene2Rx reads your GLP1R and GIPR results together for tirzepatide, so this label reflects both genes.
About tirzepatide
Tirzepatide acts on two hormone receptors: the GLP-1 receptor, like semaglutide, and the GIP receptor.
- Used for
- Blood sugar control in type 2 diabetes; long-term weight reduction in obesity, or overweight with a weight-related condition; moderate to severe obstructive sleep apnea in adults with obesity
Others in weight management
Compare all 3 weight managementDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.