GLP1RYour two copies: rs10305420C/rs10305420C
CCTypical response
The receptor that semaglutide and other GLP-1 drugs act on.
This result doesn't change the label.
Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report
Weight managementExample report
Retatrutide
Use as directed
You can expect average weight loss on this drug. Your genes also give the lowest chance of stomach side effects.
The genes behind this label
The guidelines read 2 genes for retatrutide. Each card shows the two copies this person inherited and what they mean.
GIPRYour two copies: rs1800437G/rs1800437G
Normal function
Both copies work normally.
A gut-hormone receptor that tirzepatide and retatrutide act on.
This result doesn't change the label.
What the guidelines say
What each guideline says about your result.
GLP1RTypical responseGIPRNormal function
Gene2Rx research summary, both genes together
Evidence: weakSee the drug page (Gene2Rx research summaries, opens in a new tab)
- In plain words
- You can expect average weight loss on this drug. Your genes also give the lowest chance of stomach side effects.
- What it means
- GLP1R: the more common Pro7/Pro7 form of the signal peptide (rs10305420 C/C). GIPR: full-function Glu354/Glu354 (rs1800437 G/G). This is the lowest-risk genotype pair for GI side effects. Expected weight-loss efficacy from the GLP1R arm of retatrutide. GIPR is full-function, so it adds no extra GI risk on retatrutide.
- What the research suggests
- Standard dosing and titration are expected to produce an average response.
Gene2Rx guideline extrapolated from the tirzepatide results in Su et al., Nature (2026). Retatrutide, an investigational GIP, GLP-1 and glucagon receptor agonist, has no genetic study of its own, so this assumes the GLP1R and GIPR variants act as they do with tirzepatide, which also acts on both receptors.
Gene2Rx reads your GLP1R and GIPR results together for retatrutide, so this label reflects both genes.
About retatrutide
Retatrutide is an investigational weight-loss medicine from Eli Lilly that acts on three hormone receptors: GLP-1, GIP and glucagon.
Others in weight management
Compare all 3 weight managementDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.