Drugs affected by GLP1R
About GLP1R
GLP1R is the cell-surface receptor that GLP-1 drugs like semaglutide and tirzepatide bind to. A common variant (rs10305420, Pro7Leu) changes how efficiently the receptor gets made and shipped to the cell surface. Leu7 carriers tend to lose a bit more weight on GLP-1 drugs, but they also get more nausea and vomiting.[1]
About 64% of people of European ancestry carry at least one Leu7 allele, and the allele is less common in other groups (28% Admixed American, 16% East Asian, 7% African). The association was measured most precisely in people of European ancestry. The variant doesn't decide whether a GLP-1 drug will work for someone. It changes how strong the response is and shifts the side-effect profile.
What we test for GLP1R
Gene2Rx uses definitions covering 2 named GLP1R alleles, built from 1 variant in Gene2Rx definitions. Results depend on the variants available in your upload.
- Named alleles
- 2
- Defined variants
- 1
- Source
- Gene2Rx definitions
- Genome build
- GRCh38
- Enhanced Response 1
- Typical Response 1
What do these allele names mean?
GLP1R alleles are named by the underlying DNA variant rather than a star number. For example, c.61C>T describes a single base change at position 61 of the coding sequence.
DNA variant labels identify sequence differences. Their interpretation depends on the particular gene, the evidence, and the variants that can be assessed in your data. A DNA result does not directly measure enzyme activity.
The source of these definitions is listed above. Missing variants or incomplete coverage can leave a result indeterminate.
Medications with GLP1R information
This list contains 3 medications with GLP1R information from the sources shown below. Evidence and report eligibility differ by drug; each page explains its scope and limitations.
Brand products containing a GLP1R-affected ingredient
These branded medications include at least one active ingredient whose metabolism or action involves GLP1R. Each links to its full pharmacogenetic breakdown.
References
- PharmGKB / Stanford University. PharmGKB: The Pharmacogenomics Knowledge Base. pharmgkb.org
GLP1R is one of the two genes behind GLP-1 response. Our GLP-1 genetics guide explains what each variant means for weight loss and nausea on Ozempic, Wegovy, Mounjaro, and Zepbound.
Explore GLP1R in your report
Informational only, not medical advice. The presence of a GLP1R pharmacogenetic guideline does not mean every patient needs to change their dose. Never start, stop, or change a medication without talking to your prescribing clinician.