Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

Antidepressants · TricyclicsExample report

Desipramine

Norpramin

Consider alternative

Your body breaks down desipramine much faster than normal, which may make the drug less effective. An alternative medication that is not affected by your CYP2D6 gene may be recommended.

The genes behind this label

The guidelines read one gene for desipramine. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

CPIC guideline

Evidence: optionalRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)

In plain words: Your body breaks down desipramine much faster than normal, which may make the drug less effective. An alternative medication that is not affected by your CYP2D6 gene may be recommended.
What it means: Increased metabolism of TCAs to less active compounds compared to normal metabolizers. Lower plasma concentrations of active drug will increase probability of pharmacotherapy failure.
What the guideline suggests: Avoid tricyclic use due to potential lack of efficacy. Consider alternative drug not metabolized by CYP2D6. If a TCA is warranted, consider titrating to a higher target dose (compared to normal metabolizers). Utilize therapeutic drug monitoring to guide dose adjustments.

About desipramine

Desipramine is a tricyclic antidepressant sold as Norpramin and as a generic, and it is also the active compound the body makes from imipramine.

Used for: Depression (the FDA-labeled use)

Others in antidepressants

Compare all 14 antidepressants

And 5 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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