Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report

AntiemeticsExample report

Metoclopramide

Reglan

Use with caution

Your body breaks down metoclopramide much more slowly than normal, causing the drug to build up and increasing the risk of side effects. A lower dose is recommended.

The genes behind this label

The guidelines read one gene for metoclopramide. Each card shows the two copies this person inherited and what they mean.

CYP2D6*4/*4

Poor metabolizer

Neither copy works.

0.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Poor metabolizer

FDA drug label

See the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: Your body breaks down metoclopramide much more slowly than normal, causing the drug to build up and increasing the risk of side effects. A lower dose is recommended.
What it means: Results in higher systemic concentrations and higher adverse reaction risk. The recommended dosage is lower. Refer to FDA labeling for specific dosing recommendations.
What the label suggests: Use the lower dosage the FDA label recommends.

About metoclopramide

Metoclopramide (Reglan) speeds up stomach emptying and blocks dopamine D2 receptors.

Used for: Tablets: diabetic gastroparesis, and reflux (GERD) in adults who have not responded to other therapy. Injection: also prevention of vomiting with chemotherapy and after surgery, and some procedures

Others in antiemetics

Compare all 4 antiemetics

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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