UGT1A1Your two copies: *1/*28+*60+*80
Intermediate metabolizer
One copy works and one works less well.
Clears bilirubin and some drugs, such as the cancer drug irinotecan.
This result doesn't change the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Antivirals · AntiretroviralsExample report
Atazanavir
Reyataz, Evotaz, Others
Use as directed
Your body processes atazanavir a bit more slowly than normal, but you still have a low chance of developing jaundice (yellowing of skin or eyes). The standard dose is expected to be appropriate.
The genes behind this label
The guidelines read one gene for atazanavir. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
UGT1A1Intermediate metabolizer
CPIC guideline
Evidence: strongRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body processes atazanavir a bit more slowly than normal, but you still have a low chance of developing jaundice (yellowing of skin or eyes). The standard dose is expected to be appropriate.
- What it means
- Somewhat decreased UGT1A1 activity; low likelihood of bilirubin-related discontinuation of atazanavir.
- What the guideline suggests
- There is no need to avoid prescribing of atazanavir based on UGT1A1 genetic test result. Inform the patient that some patients stop atazanavir because of jaundice (yellow eyes and skin), but that this patient’s genotype makes this unlikely
Also an ingredient in
Atazanavir is also in these combination products. The guidance above is for atazanavir on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
About atazanavir
Atazanavir is an HIV-1 protease inhibitor, taken once a day with a booster (ritonavir or cobicistat) as part of combination antiretroviral therapy.
- Used for
- HIV-1 infection, always with other antiretroviral drugs
Others in antivirals
Compare all 5 antiviralsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.