CYP2B6Your two copies: *1/*1
Normal metabolizer
Both copies work normally.
Breaks down efavirenz, ketamine, methadone and some drugs for depression.
This result doesn't change the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Antivirals · AntiretroviralsExample report
Efavirenz
Sustiva
Use as directed
Your body processes efavirenz normally. The standard dose is expected to be appropriate for you.
The genes behind this label
The guidelines read one gene for efavirenz. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2B6Normal metabolizer
CPIC guideline
Use as directed Evidence: strongRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body processes efavirenz normally. The standard dose is expected to be appropriate for you.
- What it means
- Normal efavirenz metabolism
- What the guideline suggests
- Initiate efavirenz with standard dosing (600 mg/day)
FDA drug label
Use as directed See the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- Your body processes efavirenz at a normal rate. The standard dose should work as expected.
- What it means
- No FDA guidance for your genotype
- What the label suggests
- Initiate therapy with recommended starting dose.
Also an ingredient in
Efavirenz is also in these combination products. The guidance above is for efavirenz on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
About efavirenz
Efavirenz (Sustiva, and part of several combination tablets) is an HIV-1 medicine taken once a day with other antiretrovirals.
- Used for
- HIV-1 infection, with other antiretrovirals, in adults and children at least 3 months old and 3.5 kg
Others in antivirals
Compare all 5 antiviralsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.