Nucleus Genomics Pharmacogenetics: Use Your Nucleus WGS for a PGx Report

Nucleus Genomics gives you your full genome: consumer whole genome sequencing data you can download as a VCF, packaged with long-form health interpretation. What it does not give you is a comprehensive, guideline-based report on how those genes affect your medications. That is what Gene2Rx adds. Upload your Nucleus VCF and Gene2Rx turns it into a pharmacogenetics report covering 110 medications, built on the same CPIC and FDA guidelines clinicians use. It runs in minutes, costs $5 for a starter report or $49 for the full report, plus a $15 surcharge for WGS and VCF uploads because they take more processing, so the full WGS report is $64. It needs no doctor's order and never expires, because your DNA does not change. You already paid to have your whole genome sequenced; this unlocks the part of it that affects prescriptions.

Whole genome sequencing reads every position, which is where your Nucleus data has a real edge. Genotyping chips (23andMe, AncestryDNA) tag variants at fixed positions, so they miss the rare variants that matter most for patients who do not fit the common phenotype bins; a VCF includes those. Gene2Rx reads the variant calls in your VCF, so one limit to know is that it does not detect copy-number changes such as CYP2D6 gene duplications or deletions, which require raw alignment files. And because the report is anchored to published guidelines, you can re-run it as those guidelines evolve.

Gene2Rx parses your VCF, extracts genotypes at every clinically relevant pharmacogenetic position, calls your metabolizer phenotype for each pharmacogene (poor, intermediate, normal, rapid, or ultrarapid), resolves star alleles from the variants in your VCF, and maps each phenotype to specific recommendations for 110 medications, with every recommendation traceable to its CPIC or FDA guideline. The report spans psychiatry (antidepressants, antipsychotics, ADHD medications), cardiology (clopidogrel, warfarin, statins, metoprolol), pain (codeine, tramadol), chemotherapy (capecitabine, fluorouracil), transplant, and gastrointestinal drugs. It is delivered in minutes, no new sample and no prescriber required.

Nucleus Genomics markets itself as a consumer WGS service focused on health insights, and its pharmacogenetic coverage has been expanding. But if you want a dedicated, CPIC- and FDA-anchored pharmacogenetic report covering 110 medications across all major drug classes, not just the highlights in Nucleus's built-in reports, running your VCF through a service designed specifically for pharmacogenetic analysis gives you the deepest coverage. You already own the sequencing that makes it possible.

Clinical pharmacogenetic tests like GeneSight run from a few hundred to a few thousand dollars, need a new DNA sample, and require a provider order. Because you already have Nucleus WGS data, none of that applies: a Gene2Rx report is $5 for the starter tier or $49 for the full report, plus a $15 surcharge for WGS and VCF uploads (so the full WGS report is $64), with no lab work to repeat. Your pharmacogenetic profile does not change over time, so a single report is a reference you will use for decades of prescribing decisions.

These are the main genes Gene2Rx reads out of your Nucleus VCF and what each one affects. The biology is the same no matter which data source you start from; what Nucleus provides is the raw sequence at these positions.

Your Nucleus VCF contains the sequence for all of these genes; the only thing standing between that and actionable guidance is interpretation. Gene2Rx translates your genotypes into metabolizer phenotypes for each gene, then maps those phenotypes to specific medication recommendations anchored to CPIC^[8] and FDA^[9] guidelines, so the output reads the same way a clinical pharmacogenetic report would.

If you already have Nucleus Genomics WGS data, there is little reason to wait: the data exists and the starter report is $5 (plus the $15 WGS surcharge). It is most valuable if you are starting or already taking a medication with pharmacogenetic guidelines, if you have had side effects or poor response in the past, or if you simply want the information on file for future prescribing. Because your genotype never changes, one report serves you for life.

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Yes. Nucleus provides access to your raw sequencing data including a VCF file. The exact export path depends on your Nucleus subscription tier; check your account for the download option.

Nucleus offers integrated health interpretation covering a broad range of topics. Gene2Rx is specifically focused on pharmacogenetics and covers more medications (110) with CPIC-anchored per-phenotype recommendations. They can complement each other: Nucleus for broad health insights, your Gene2Rx report for a pharmacogenetic deep-dive on your medications.

Yes. The underlying genetic variants are the same whether sequenced by Nucleus, a clinical lab, or any other reputable WGS provider, and WGS covers more variant positions than a genotyping chip can. The interpretation follows the same CPIC and FDA guidelines a clinical test would use. The difference between Gene2Rx and a clinical test like GeneSight is about workflow (direct-to-consumer versus prescriber-ordered) and medication breadth, not the accuracy of the phenotype calls.

The starter report is $5 and the full 110-medication report is $49. WGS and VCF uploads carry a $15 surcharge because they take more processing, so the full WGS report is $64. You can start with the starter tier and upgrade later.