Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

Pain managementExample report

Tramadol

Ultram, ConZip

Consider alternative

Your body turns this drug into its active form too fast, which raises the risk of serious side effects. A different pain medicine is advised.

The genes behind this label

The guidelines read one gene for tramadol. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

CPIC guideline

Consider alternative Evidence: strongRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)

In plain words: Your body turns this drug into its active form too fast, which raises the risk of serious side effects. A different pain medicine is advised.
What it means: Increased formation of O-desmethyltramadol (active metabolite) leading to higher risk of toxicity
What the guideline suggests: Avoid tramadol use because of potential for toxicity. If opioid use is warranted, consider a non-codeine opioid.

FDA drug label

Consider alternative Evidence: strongSee the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: Your body turns this drug into its active form too fast. This can cause dangerous breathing problems, especially in children and breastfed babies. A different pain medicine is advised.
What it means: Results in higher systemic and breast milk active metabolite concentrations, which may result in respiratory depression and death. Contraindicated in children under 12 and in adolescents following tonsillectomy/adenoidectomy. Breastfeeding is not recommended during treatment.
What the label suggests: Avoid use. Use an alternative analgesic that is not metabolized by CYP2D6. Contraindicated in children under 12 and adolescents following tonsillectomy/adenoidectomy. Breastfeeding is not recommended.

Also an ingredient in

Tramadol is also in these combination products. The guidance above is for tramadol on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.

About tramadol

Tramadol is a prescription pain medicine with two actions: it is a weak opioid, and it slows the reuptake of serotonin and norepinephrine.

Used for: Pain in adults that is severe enough to need an opioid and for which other treatments are not enough

Others in pain management

Compare all 13 pain management

And 4 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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