Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

Pain managementExample report

Codeine

Tylenol 3

Consider alternative

Your body turns codeine into morphine too fast, which can cause dangerous side effects. A different pain reliever is usually suggested.

The genes behind this label

The guidelines read one gene for codeine. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

CPIC guideline

Consider alternative Evidence: strongRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)

In plain words: Your body turns codeine into morphine too fast, which can cause dangerous side effects. A different pain reliever is usually suggested.
What it means: Increased formation of morphine leading to higher risk of toxicity
What the guideline suggests: Avoid codeine use because of potential for serious toxicity. If opioid use is warranted, consider a non-tramadol opioid.

FDA drug label

Consider alternative See the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: Your body turns codeine into morphine too fast. This can cause dangerous side effects, such as slowed breathing. A different pain reliever is usually suggested.
What it means: Results in higher systemic active metabolite concentrations and higher adverse reaction risk (life-threatening respiratory depression and death). Codeine is contraindicated in children under 12 years of age.
What the label suggests: Codeine is contraindicated in children under 12 years. Refer to FDA labeling, which warns of life-threatening respiratory depression in ultrarapid metabolizers.

Also an ingredient in

Codeine is also in these combination products. The guidance above is for codeine on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.

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About codeine

Codeine is an opioid prescribed for mild to moderate pain and, in some prescription syrups, for cough.

Used for: Mild to moderate pain when an opioid is appropriate and other treatments are not enough; cough in adults (combination syrups)

Others in pain management

Compare all 13 pain management

And 4 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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