UGT1A1Your two copies: *1/*60
Normal metabolizer
Both copies work normally.
Clears bilirubin and some drugs, such as the cancer drug irinotecan.
This result doesn't change the label.
Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report
Oncology · ChemotherapiesExample report
Sacituzumab Govitecan-Hziy
Trodelvy
Use as directed
Your body processes sacituzumab govitecan at a normal rate. The standard dose should work as expected.
The genes behind this label
The guidelines read one gene for sacituzumab govitecan-hziy. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
UGT1A1Normal metabolizer
- In plain words
- Your body processes sacituzumab govitecan at a normal rate. The standard dose should work as expected.
- What it means
- No FDA guidance for this phenotype
- What the label suggests
- Initiate therapy with recommended starting dose.
About sacituzumab govitecan-hziy
Sacituzumab govitecan-hziy (Trodelvy) is an antibody-drug conjugate for advanced breast cancer: an antibody that seeks out the Trop-2 protein on cancer cells, carrying SN-38, the active form of the chemotherapy drug irinotecan.
- Used for
- Locally advanced or metastatic triple-negative breast cancer, and HR-positive, HER2-negative breast cancer after earlier treatments
Others in oncology
Compare all 13 oncology- BelinostatBeleodaq Use as directed
- BelzutifanWelireg Use as directed
- CapecitabineXeloda, Xitabin, Kapetral Use as directed
- ErdafitinibBalversa Use as directed
- FluorouracilAdrucil, Carac Use as directed
- GefitinibIressa Use as directed
- IrinotecanCamptosar, Onivyde Use as directed
- MercaptopurinePurinethol Use as directed
Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.