CYP2D6Your two copies: *4/*4
Poor metabolizer
Neither copy works.
0.0 activity scoreTypical: 1.25 to 2.25Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Movement disorders · Involuntary Movement ReducersExample report
Valbenazine
Ingrezza
Use with caution
Your body breaks down valbenazine much more slowly than normal, causing the drug to build up. This raises your risk of heart rhythm problems, so a lower dose may be needed.
The genes behind this label
The guidelines read one gene for valbenazine. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2D6Poor metabolizer
- In plain words
- Your body breaks down valbenazine much more slowly than normal, causing the drug to build up. This raises your risk of heart rhythm problems, so a lower dose may be needed.
- What it means
- Results in higher systemic active metabolite concentrations and may result in higher adverse reaction risk (QT prolongation). The recommended dosage for poor metabolizers is 40 mg once daily.
- What the label suggests
- The recommended dosage for poor metabolizers is 40 mg once daily.
About valbenazine
Valbenazine (Ingrezza, Ingrezza Sprinkle) treats tardive dyskinesia and the chorea of Huntington's disease in adults.
- Used for
- Tardive dyskinesia; chorea associated with Huntington's disease (adults)
Others in movement disorders
Compare all 3 movement disordersDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.