CYP3A5Your two copies: *1/*3
Intermediate metabolizer
One copy works and one doesn't.
Breaks down tacrolimus, a drug used after organ transplants.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
ImmunosuppressantsExample report
Tacrolimus
Prograf
Use with caution
Your body breaks down this drug faster than many people do, so the usual dose may fall short. A higher starting dose and blood tests are advised.
The genes behind this label
The guidelines read one gene for tacrolimus. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP3A5Intermediate metabolizer
CPIC guideline
Use with caution Evidence: strongRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body breaks down this drug faster than many people do, so the usual dose may fall short. A higher starting dose and blood tests are advised.
- What it means
- Lower dose-adjusted trough concentrations of tacrolimus and decreased chance of achieving target tacrolimus concentrations
- What the guideline suggests
- Increase starting dose 1.5 to 2 times recommended starting dose. Total starting dose should not exceed 0.3mg/kg/day. Use therapeutic drug monitoring to guide dose adjustments
FDA drug label
Use with caution See the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- Your body processes tacrolimus at a moderate rate. Your dose may need to be adjusted based on blood level monitoring to make sure you get the right amount.
- What it means
- Results in lower systemic concentrations, lower probability of achieving target concentrations and may result in higher rejection risk. Measure drug concentrations and adjust dosage based on trough whole blood tacrolimus concentrations.
- What the label suggests
- Measure drug concentrations and adjust the dosage based on trough whole blood tacrolimus concentrations.
About tacrolimus
Tacrolimus (Prograf and other brands) is an immunosuppressant taken after organ transplants to prevent rejection.
- Used for
- Preventing rejection after kidney, liver, heart or lung transplant
Others in immunosuppressants
Compare all 4 immunosuppressantsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.