ABCG2Your two copies: rs2231142G/rs2231142G
Normal function
Both copies work normally.
A pump that clears uric acid and some drugs, such as rosuvastatin, from the body.
This result doesn't change the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
GoutExample report
Allopurinol
Zyloprim
Use as directed
Your ABCG2 genotype does not change how you respond to allopurinol; standard dosing applies.
The genes behind this label
The guidelines read one gene for allopurinol. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
ABCG2Normal function
DPWG guideline
Evidence: moderateRead the guideline (Dutch Pharmacogenetics Working Group, opens in a new tab)
- In plain words
- Your ABCG2 genotype does not change how you respond to allopurinol; standard dosing applies.
- What it means
- Normal ABCG2 transporter function. Renal and intestinal uric acid excretion is not impaired by ABCG2 variation at p.Gln141Lys.
- What the guideline suggests
- Use standard allopurinol dosing.
Also an ingredient in
Allopurinol is also in these combination products. The guidance above is for allopurinol on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
About allopurinol
Allopurinol (Zyloprim) lowers uric acid by blocking the enzyme xanthine oxidase, and it is the usual first-line treatment for the high uric acid that causes gout.
- Used for
- Gout (attacks, tophi, uric acid stones); high uric acid caused by cancer treatment; recurrent calcium oxalate kidney stones with high urine uric acid
Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.