Drugs affected by CYP4F2
About CYP4F2
CYP4F2 metabolizes vitamin K. A variant called V433M (rs2108622) reduces enzyme activity, so more vitamin K reaches the clotting cascade. Carriers therefore need slightly higher warfarin doses to achieve the same anticoagulant effect, on top of the much larger effects of CYP2C9 and VKORC1.[1]
CYP4F2 is included in modern warfarin dosing algorithms alongside CYP2C9 and VKORC1. The single-gene effect is small, but the three genes together substantially improve dose prediction.[2]
What we test for CYP4F2
Gene2Rx uses definitions covering 3 named CYP4F2 star alleles, built from 2 variants in Gene2Rx definitions. Results depend on the variants available in your upload.
- Star alleles
- 3
- Defined variants
- 2
- Source
- Gene2Rx definitions
- Genome build
- GRCh38
- Normal Function 1
- Decreased Function 1
- Unknown Function 1
What are star alleles?
Star alleles (like *1, *2, *4) are standardized names for distinct versions of a pharmacogene. *1 is the reference; other numbers identify distinct allele definitions. A higher number does not mean lower function.
You inherit one allele from each parent, so your genotype is a pair (e.g. *1/*4). The pair determines your predicted phenotype: for example, whether you metabolize a drug at a normal, decreased, or no-function rate.
PharmVar is the international registry that defines and curates these allele names. Gene2Rx uses the supported definitions summarized here. Coverage depends on the variants present in your input; this is not a guarantee that every cataloged allele can be identified.
Medications with CYP4F2 information
This list contains 1 medication with CYP4F2 information from the sources shown below. Evidence and report eligibility differ by drug; each page explains its scope and limitations.
blood thinners
Brand products containing a CYP4F2-affected ingredient
These branded medications include at least one active ingredient whose metabolism or action involves CYP4F2. Each links to its full pharmacogenetic breakdown.
References
- CPIC. CPIC Guideline for Pharmacogenetics-Guided Warfarin Dosing (CYP2C9, VKORC1, CYP4F2) (2017). cpicpgx.org
- PharmGKB / Stanford University. PharmGKB: The Pharmacogenomics Knowledge Base. pharmgkb.org
Explore CYP4F2 in your report
Informational only, not medical advice. The presence of a CYP4F2 pharmacogenetic guideline does not mean every patient needs to change their dose. Never start, stop, or change a medication without talking to your prescribing clinician.