Combination medications and your genes

Pharmacogenetic guidelines are written for one ingredient at a time. Here is how they apply to products like Tylenol with Codeine, Excedrin and Adderall, and every combination product we track with an ingredient that has guidance.

How we handle them

Guidance is per ingredient. The guidelines from CPIC, the FDA and DPWG cover single ingredients. None of them covers a combination product as a whole.

We look at each ingredient. If an ingredient has guidance, the product carries that ingredient's guidance. The other ingredients, like the acetaminophen in Tylenol with Codeine, usually have none.

What it means for the combination is less clear. The dose of each ingredient can differ from the single-ingredient product, and the ingredients can change how each other works. Treat the ingredient's guidance as a reason to talk with your prescriber or pharmacist, not as advice about the product itself.

In your report. Combination products aren't listed in a Gene2Rx report on their own. Search for one by name in your report to see your result for each ingredient your report covers.

Products by ingredient

61 combination products, listed under each ingredient that has pharmacogenetic guidance. A product with two such ingredients shows under both.

Codeine18
Caffeine8
Ibuprofen8
Hydrocodone5
Ivacaftor3
Omeprazole3
Amitriptyline2
Carisoprodol2
Celecoxib2
Efavirenz2
Meloxicam2
Tramadol2
Allopurinol1
Amphetamine1
Atazanavir1
Atorvastatin1
Hydralazine1
Lansoprazole1
Metoprolol1
Perphenazine1
Rosuvastatin1
Simvastatin1

Codeine

Codeine and your genes

Acetaminophen, butalbital, caffeine and codeine

Fioricet with Codeine

Also contains acetaminophen, butalbital, caffeine
Acetaminophen and codeine

Tylenol #3, Tylenol with Codeine

Also contains acetaminophen
Aspirin, butalbital, caffeine and codeine

Ascomp

Also contains aspirin, butalbital, caffeine
Aspirin, carisoprodol and codeine

Also contains aspirin, carisoprodol
Brompheniramine and codeine

BroveX CB

Also contains brompheniramine
Brompheniramine, codeine and phenylephrine

Brovex PBC, M-End PE

Also contains brompheniramine, phenylephrine
Brompheniramine, codeine and pseudoephedrine

Also contains brompheniramine, pseudoephedrine
Chlorpheniramine and codeine

Tuxarin

Also contains chlorpheniramine
Chlorpheniramine, codeine and phenylephrine

Also contains chlorpheniramine, phenylephrine
Chlorpheniramine, codeine and pseudoephedrine

Also contains chlorpheniramine, pseudoephedrine
Codeine and dexbrompheniramine

Duratuss AC

Also contains dexbrompheniramine
Codeine, dexbrompheniramine and pseudoephedrine

M-End Max D

Also contains dexbrompheniramine, pseudoephedrine
Codeine, dexchlorpheniramine and phenylephrine

Also contains dexchlorpheniramine, phenylephrine
Codeine and guaifenesin

Cheratussin, M-Clear WC, Mar-cof CG, Ninjacof XG

Also contains guaifenesin
Codeine, guaifenesin and pseudoephedrine

Lortuss EX

Also contains guaifenesin, pseudoephedrine
Codeine, phenylephrine and promethazine

Also contains phenylephrine, promethazine
Codeine, phenylephrine and triprolidine

Also contains phenylephrine, triprolidine
Codeine and promethazine

Also contains promethazine

Caffeine

Caffeine and your genes

Acetaminophen, aspirin and caffeine

Excedrin, Anacin Advanced Headache Formula, Arthriten Inflammatory Pain, Backaid IPF, Pamprin Max Formula, Vanquish

Also contains acetaminophen, aspirin
Acetaminophen, butalbital and caffeine

Fioricet, Capacet, Esgic, Repan, Vanatol, Vtol, Zebutal

Also contains acetaminophen, butalbital
Acetaminophen, butalbital, caffeine and codeine

Fioricet with Codeine

Also contains acetaminophen, butalbital, codeine
Acetaminophen and caffeine

Excedrin Tension Headache, Excedrin Mild Headache, Excedrin Quick Tab, Panadol Extra

Also contains acetaminophen
Acetaminophen, caffeine and pyrilamine

Midol Complete

Also contains acetaminophen, pyrilamine
Aspirin, butalbital and caffeine

Fiorinal

Also contains aspirin, butalbital
Aspirin, butalbital, caffeine and codeine

Ascomp

Also contains aspirin, butalbital, codeine
Aspirin and caffeine

Anacin, BC Arthritis, BC Original Formula, Stanback Headache Powder

Also contains aspirin

Ibuprofen

Ibuprofen and your genes

Acetaminophen and ibuprofen

Advil Dual Action, Combogesic

Also contains acetaminophen
Chlorpheniramine, ibuprofen and phenylephrine

Advil Allergy and Congestion Relief, Advil Multi-Symptom Cold and Flu

Also contains chlorpheniramine, phenylephrine
Chlorpheniramine, ibuprofen and pseudoephedrine

Advil Allergy Sinus

Also contains chlorpheniramine, pseudoephedrine
Diphenhydramine and ibuprofen

Advil PM, Motrin PM

Also contains diphenhydramine
Famotidine and ibuprofen

Duexis

Also contains famotidine
Hydrocodone and ibuprofen

Vicoprofen, Ibudone, Reprexain

Also contains hydrocodone
Ibuprofen and phenylephrine

Advil Sinus Congestion and Pain, Sudafed PE Head Congestion Plus Pain

Also contains phenylephrine
Ibuprofen and pseudoephedrine

Advil Cold and Sinus

Also contains pseudoephedrine

Hydrocodone

Hydrocodone and your genes

Acetaminophen and hydrocodone

Vicodin, Hycet, Norco, Verdrocet

Also contains acetaminophen
Chlorpheniramine and hydrocodone

Also contains chlorpheniramine
Guaifenesin and hydrocodone

Obredon

Also contains guaifenesin
Homatropine and hydrocodone

Hycodan, Hydromet

Also contains homatropine
Hydrocodone and ibuprofen

Vicoprofen, Ibudone, Reprexain

Also contains ibuprofen

Ivacaftor

Ivacaftor and your genes

Elexacaftor, ivacaftor and tezacaftor

Trikafta

Also contains elexacaftor, tezacaftor
Ivacaftor and lumacaftor

Orkambi

Also contains lumacaftor
Ivacaftor and tezacaftor

Symdeko

Also contains tezacaftor

Omeprazole

Omeprazole and your genes

Amoxicillin, omeprazole and rifabutin

Talicia

Also contains amoxicillin, rifabutin
Aspirin and omeprazole

Yosprala

Also contains aspirin
Omeprazole and sodium bicarbonate

Konvomep, Zegerid

Also contains sodium bicarbonate

Amitriptyline

Amitriptyline and your genes

Amitriptyline and chlordiazepoxide

Also contains chlordiazepoxide
Amitriptyline and perphenazine

Also contains perphenazine

Carisoprodol

Carisoprodol and your genes

Aspirin and carisoprodol

Also contains aspirin
Aspirin, carisoprodol and codeine

Also contains aspirin, codeine

Celecoxib

Celecoxib and your genes

Amlodipine and celecoxib

Consensi

Also contains amlodipine
Celecoxib and tramadol

Seglentis

Also contains tramadol

Efavirenz

Efavirenz and your genes

Efavirenz, emtricitabine and tenofovir disoproxil

Atripla

Also contains emtricitabine, tenofovir disoproxil
Efavirenz, lamivudine and tenofovir disoproxil

Symfi

Also contains lamivudine, tenofovir disoproxil

Meloxicam

Meloxicam and your genes

Bupivacaine and meloxicam

Zynrelef

Also contains bupivacaine
Meloxicam and rizatriptan

Symbravo

Also contains rizatriptan

Tramadol

Tramadol and your genes

Acetaminophen and tramadol

Ultracet

Also contains acetaminophen
Celecoxib and tramadol

Seglentis

Also contains celecoxib

Allopurinol

Allopurinol and your genes

Allopurinol and lesinurad

Also contains lesinurad

Amphetamine

Amphetamine and your genes

Amphetamine and dextroamphetamine

Adderall, Mydayis

Also contains dextroamphetamine

Atazanavir

Atazanavir and your genes

Atazanavir and cobicistat

Evotaz

Also contains cobicistat

Atorvastatin

Atorvastatin and your genes

Amlodipine and atorvastatin

Caduet

Also contains amlodipine

Hydralazine

Hydralazine and your genes

Hydralazine and isosorbide dinitrate

Bidil

Also contains isosorbide dinitrate

Lansoprazole

Lansoprazole and your genes

Amoxicillin, clarithromycin and lansoprazole

Also contains amoxicillin, clarithromycin

Metoprolol

Metoprolol and your genes

Hydrochlorothiazide and metoprolol

Lopressor HCT

Also contains hydrochlorothiazide

Perphenazine

Perphenazine and your genes

Amitriptyline and perphenazine

Also contains amitriptyline

Rosuvastatin

Rosuvastatin and your genes

Ezetimibe and rosuvastatin

Roszet

Also contains ezetimibe

Simvastatin

Simvastatin and your genes

Ezetimibe and simvastatin

Vytorin

Also contains ezetimibe

Product names come from RxNorm, the US National Library of Medicine's list of prescribable drugs, plus brands we've added by hand. Informational only, not medical advice. Never start, stop, or change a medication without talking to your prescribing clinician.