Existing PGx results / GeneSight

Use the genotypes in your GeneSight report

Enter the genotypes from your GeneSight report and get a Gene2Rx Panel Report: every covered medication interpreted against current CPIC, FDA, and DPWG guidance, not just the ones on your original report.

How it works

  1. Enter your genotypes

    Pick the two star alleles for each gene on your report, such as CYP2D6 *1/*4.

  2. Check your coverage

    See which medications your results cover before you pay.

  3. Get your report

    Your Panel Report is ready in your account within minutes, as a web page and a PDF.

Where to find your genotypes in a GeneSight report

Look for the section titled Patient Genotypes and Phenotypes. Each gene is listed with its genotype, such as CYP2C19 *1/*2, next to a metabolizer label. The genotype is what you enter. Layouts change between report versions, so go by the section title rather than a page number.

  1. Find each gene below that appears on your report and copy both of its alleles.
  2. If CYP2D6 shows a duplication such as *2xN or *1x2, choose the allele and its number of copies. When the count isn't listed, Gene2Rx assumes two copies and tells you if a third copy would change the result.
  3. Leave a gene blank if it isn't on your report, or if it's shown as a DNA change rather than star alleles (GeneSight lists CYP1A2 as -163C>A, for example). The green, yellow, and red medication groups can't stand in for a missing genotype.

GeneSight's medication groups combine several genes using its own method. Gene2Rx interprets each gene with published CPIC, FDA, and DPWG guidance, so some medications may be grouped differently. How to read a GeneSight report.

GeneSight's sample report shows where this section is.

Genes you can enter

CYP2D6CYP2C19CYP2C9CYP3A4CYP3A5CYP2B6CYP1A2SLCO1B1UGT1A1TPMTNUDT15DPYDVKORC1CYP4F2COMT

These cover most of the drug-metabolism genes on GeneSight, Genomind, and clinical PGx panel reports. CYP2D6 duplications (such as *2xN) and tandems (such as *36+*10) are supported.

You can also enter ABCG2, ADH1B, AKT1, ALDH2, BCHE, CACNA1S, CHRNA5, CYP2A6, FAAH, GIPR, GLP1R, IFNL3, NAT2, RYR1, SULT1A1, including single-variant results such as rs4680 G/A. Results reported only as a phenotype or a color category can't be entered, and genes such as HLA, MTHFR, SLC6A4, and HTR2A aren't supported. Medications that depend only on genes you don't enter won't be in your report.

What you get

$19 one time

Questions

Can I use my GeneSight results with Gene2Rx?

Yes. Copy the genotype for each gene from the Patient Genotypes and Phenotypes section, such as CYP2C19 *1/*2, and Gene2Rx interprets it for every medication in its guideline set, not just the psychiatric medications GeneSight covers. The report costs $19 and no new sample is needed.

What if my CYP2D6 result says xN?

xN means the lab found extra copies of that allele without reporting how many. Choose the allele and "×N (not listed)". Gene2Rx assumes two copies, the most common count, and if a third copy would change your metabolizer status, your report says so and shows the result for both counts.

Will Gene2Rx use GeneSight's green, yellow, and red groups?

No. GeneSight's groups combine several genes using its own method. Gene2Rx interprets each gene with published CPIC, FDA, and DPWG guidance, so some medications may be grouped differently. A difference doesn't mean either report is wrong; discuss it with your clinician. How to read a GeneSight report.

Does Gene2Rx verify my results?

No. We check that each genotype is one we can interpret, but we never see your laboratory report, so copy your results carefully. If you mistype a genotype, you can correct it later at no charge.

Have a 23andMe or AncestryDNA file instead?

Raw data files cover more genes, so a report from your file is usually more complete. See our raw-data reports.

GeneSight is a trademark of its owner. Gene2Rx is independent and is not affiliated with or endorsed by GeneSight.

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