Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

AntiemeticsExample report

Tropisetron

Navoban

Consider alternative

Your body breaks down this drug very fast, so it may not stop nausea well. A different anti-nausea drug is often suggested.

The genes behind this label

The guidelines read one gene for tropisetron. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

CPIC guideline

Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)

In plain words: Your body breaks down this drug very fast, so it may not stop nausea well. A different anti-nausea drug is often suggested.
What it means: Increased metabolism to less active compounds when compared to normal metabolizers and is associated with decreased response to ondansetron and tropisetron (i.e. vomiting).
What the guideline suggests: Select alternative drug not predominantly metabolized by CYP2D6 (i.e., granisetron).

About tropisetron

Tropisetron is a serotonin 5-HT3 receptor blocker used outside the United States to prevent nausea and vomiting, for example with cancer chemotherapy; no tropisetron product is approved by the FDA.

Used for: Preventing nausea and vomiting, including with cancer chemotherapy

Others in antiemetics

Compare all 4 antiemetics

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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