Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

Oncology · Estrogen ModulatorsExample report

Tamoxifen

Nolvadex, Soltamox

Use as directed

Your body turns this drug into its active form well. The usual dose should work.

The genes behind this label

The guidelines read one gene for tamoxifen. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result doesn't change the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

CPIC guideline

Evidence: strongRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)

In plain words: Your body turns this drug into its active form well. The usual dose should work.
What it means: Therapeutic endoxifen concentrations
What the guideline suggests: Avoid moderate and strong CYP2D6 inhibitors. Initiate therapy with recommended standard of care dosing (tamoxifen 20 mg/day).

About tamoxifen

Tamoxifen is a hormonal therapy for estrogen receptor-positive breast cancer, used after surgery to lower the chance of recurrence, for advanced disease, and to reduce breast cancer risk in women at high risk.

Used for: Estrogen receptor-positive breast cancer: treatment after surgery (adjuvant) and of metastatic disease; reducing the risk of invasive breast cancer after DCIS and in women at high risk

Others in oncology

Compare all 13 oncology

And 4 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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