Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report
Sustiva
Unable to determine
The impact of your genotype on response to this drug is unknown
The guidelines read one gene for efavirenz. Each card shows the two copies this person inherited and what they mean.
Unable to determine
One copy (*9) works less well. The other (*18) also carries a variant that doesn't match any known version of the gene. So we can't say how well CYP2B6 works overall.
Breaks down efavirenz, ketamine, methadone and some drugs for depression.
No clear result for this gene (see above), so its part in the label is unknown.
What each guideline says about your result.
CYP2B6Indeterminate
CPIC guideline
Unable to determine Read the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
FDA drug label
Unable to determine See the FDA table (U.S. Food and Drug Administration, opens in a new tab)
Efavirenz is also in these combination products. The guidance above is for efavirenz on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
Efavirenz (Sustiva, and part of several combination tablets) is an HIV-1 medicine taken once a day with other antiretrovirals.
Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.
