CYP2C19Your two copies: *1/*2
Intermediate metabolizer
One copy works and one doesn't.
Handles several SSRIs, acid reducers such as omeprazole, and the blood thinner clopidogrel.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
AntifungalsExample report
Voriconazole
Vfend
Use with caution
Your body breaks down this drug more slowly, so levels can rise and side effects are more likely.
The genes behind this label
The guidelines read one gene for voriconazole. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2C19Intermediate metabolizer
CPIC guideline
Use as directed Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body breaks down this drug a bit more slowly, so levels may run a little higher. The usual dose is still advised.
- What it means
- Higher dose-adjusted trough concentrations of voriconazole compared to normal metabolizers.
- What the guideline suggests
- Initiate therapy with recommended standard of care dosing.
FDA drug label
Use with caution Evidence: moderateSee the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- Your body breaks down this drug more slowly, so levels can rise and side effects are more likely.
- What it means
- Results in higher systemic concentrations and may result in higher adverse reaction risk.
- What the label suggests
- No specific dosing change in the FDA table. Refer to FDA labeling.
About voriconazole
Voriconazole (Vfend) is a triazole antifungal used for serious infections such as invasive aspergillosis.
- Used for
- Invasive aspergillosis, candidemia and other deep Candida infections, esophageal candidiasis, and Scedosporium and Fusarium infections, in adults and children 2 and older
Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.