Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report

Drugs used in addictive disordersExample report

Lofexidine

Lucemyra

Use with caution

Your body breaks down lofexidine more slowly than normal, causing it to build up in your system. This increases the risk of side effects like low blood pressure and a slow heart rate.

The genes behind this label

The guidelines read one gene for lofexidine. Each card shows the two copies this person inherited and what they mean.

CYP2D6*4/*4

Poor metabolizer

Neither copy works.

0.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Poor metabolizer

FDA drug label

See the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: Your body breaks down lofexidine more slowly than normal, causing it to build up in your system. This increases the risk of side effects like low blood pressure and a slow heart rate.
What it means: Results in higher systemic concentrations and higher adverse reaction risk. Monitor for orthostatic hypotension and bradycardia.
What the label suggests: Monitor for orthostatic hypotension and bradycardia.

About lofexidine

Lofexidine (Lucemyra) eases the symptoms of opioid withdrawal in adults who are stopping opioids abruptly.

Used for: Easing opioid withdrawal symptoms to help adults stop opioids abruptly