Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report

Gaucher's disease treatmentsExample report

Eliglustat

Cerdelga

Use with caution

Your body breaks down this drug much more slowly, which can raise the risk of heart rhythm problems. Your doctor will set your dose, and some other medicines can't be taken with it.

The genes behind this label

The guidelines read one gene for eliglustat. Each card shows the two copies this person inherited and what they mean.

CYP2D6*4/*4

Poor metabolizer

Neither copy works.

0.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Poor metabolizer

FDA drug label

See the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: Your body breaks down this drug much more slowly, which can raise the risk of heart rhythm problems. Your doctor will set your dose, and some other medicines can't be taken with it.
What it means: Alters systemic concentrations, effectiveness, and adverse reaction risk (QT prolongation). Coadministration with strong CYP3A inhibitors is contraindicated in intermediate and poor CYP2D6 metabolizers. Refer to FDA labeling for specific dosing recommendations.
What the label suggests: Use the dosage the FDA label gives for CYP2D6 poor metabolizers. Coadministration with strong CYP3A inhibitors is contraindicated.

About eliglustat

Eliglustat (Cerdelga) is a capsule for adults with Gaucher disease type 1.

Used for: Long-term treatment of adults with Gaucher disease type 1 who are CYP2D6 normal (extensive), intermediate or poor metabolizers