CYP2C19Your two copies: *1/*2
Intermediate metabolizer
One copy works and one doesn't.
Handles several SSRIs, acid reducers such as omeprazole, and the blood thinner clopidogrel.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
AnticonvulsantsExample report
Clobazam
Onfi, Frisium
Use with caution
Your body breaks down clobazam more slowly than normal, causing higher levels of the drug's active form to build up. A lower dose may be needed to reduce the risk of side effects.
The genes behind this label
The guidelines read one gene for clobazam. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2C19Intermediate metabolizer
- In plain words
- Your body breaks down clobazam more slowly than normal, causing higher levels of the drug's active form to build up. A lower dose may be needed to reduce the risk of side effects.
- What it means
- Results in higher systemic active metabolite concentrations. Poor metabolism results in higher adverse reaction risk. Dosage adjustment is recommended. Refer to FDA labeling for specific dosing recommendations.
- What the label suggests
- Dosage adjustment is recommended; the FDA label gives specific dosing for poor metabolizers.
About clobazam
Clobazam (Onfi, Sympazan) is a benzodiazepine used alongside other medicines to treat seizures in Lennox-Gastaut syndrome, a severe childhood-onset epilepsy.
- Used for
- Add-on treatment of seizures associated with Lennox-Gastaut syndrome, age 2 and older
Others in anticonvulsants
Compare all 4 anticonvulsantsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.