Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report

PsychostimulantsExample report

Atomoxetine

Strattera

Use with caution

Your body processes this drug very slowly, so it builds up. It may work well but cause more side effects, so your doctor may start low and go slowly.

The genes behind this label

The guidelines read one gene for atomoxetine. Each card shows the two copies this person inherited and what they mean.

Poor metabolizer

Neither copy works.

0.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What each guideline says about your result.

CYP2D6Poor metabolizer (activity score 0.0)

CPIC guideline

In plain words: Your body processes this drug very slowly, so it builds up. It may work well but cause more side effects, so your doctor may start low and go slowly.
What it means: Significantly decreased metabolism of atomoxetine may result in higher concentrations as compared to non- poor metabolizers. This may increase the occurrence of treatment-emergent side effects, but also a greater improvement of ADHD symptoms as compared with non- poor metabolizers in those who tolerate treatment. Poor metabolizer status is associated with lower final dose requirements as compared to non- poor metabolizers.
What the guideline suggests: Initiate with a dose of 40 mg/day and if no clinical response and in the absence of adverse events after 2 weeks increase dose to 80 mg/day. If response is inadequate after 2 weeks consider obtaining a plasma concentration 2-4 h after dosing. If concentration is <200 ng/ml, consider a proportional dose increase to achieve a concentration to approach 400 ng/ml. If unacceptable side effects are present at any time, consider a reduction in dose.

FDA drug label

In plain words: Your body breaks down atomoxetine more slowly than normal, causing it to build up in your system. A lower dose or slower dose increases may be needed to reduce the risk of side effects.
What it means: Results in higher systemic concentrations and higher adverse reaction risk. Adjust titration interval and increase dosage if tolerated. Refer to FDA labeling for specific dosing recommendations.
What the label suggests: Adjust the titration interval and increase the dosage only if tolerated, as the FDA label directs.

Atomoxetine (Strattera) is a non-stimulant ADHD medicine for adults and children 6 and older.

Used for: Attention-deficit/hyperactivity disorder (ADHD) in adults and children 6 and older

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.