Drugs affected by CFTR
About CFTR
CFTR is the chloride channel that's broken in cystic fibrosis. Modern CF therapies (ivacaftor, tezacaftor, elexacaftor, and their combinations) restore partial channel function, but only for patients whose specific CFTR variant produces a protein the drugs can act on.[1] The FDA labels each modulator with the exact list of responsive variants.[2]
Patients with at least one gating variant like G551D respond dramatically to ivacaftor. Patients homozygous for F508del benefit from the triple combination (Trikafta), but not from ivacaftor alone.
Medications with CFTR information
This list contains 1 medication with CFTR information from the sources shown below. Evidence and report eligibility differ by drug; each page explains its scope and limitations.
cystic fibrosis treatment
Brand products containing a CFTR-affected ingredient
These branded medications include at least one active ingredient whose metabolism or action involves CFTR. Each links to its full pharmacogenetic breakdown.
References
- U.S. Food and Drug Administration. Table of Pharmacogenomic Biomarkers in Drug Labeling (2024). fda.gov
- PharmGKB / Stanford University. PharmGKB: The Pharmacogenomics Knowledge Base. pharmgkb.org
Explore CFTR in your report
Informational only, not medical advice. The presence of a CFTR pharmacogenetic guideline does not mean every patient needs to change their dose. Never start, stop, or change a medication without talking to your prescribing clinician.