Is Clopixol affected by genetics?
Yes. Its active ingredient has published pharmacogenetic guidance for a gene that varies between people.
Clopixol is affected by pharmacogenetics through the CYP2D6 gene. Your genotype for this gene can change how well Clopixol works for you or how well you tolerate it. The strongest evidence level on this page is Moderate, from the published guidelines shown below.
What's in Clopixol
Zuclopenthixol Affected by CYP2D6
Affected by CYP2D6. Guidance from DPWG, moderate evidence.
Read the full zuclopenthixol genetics guideZuclopenthixol phenotype recommendations
Published guidance from DPWG on how zuclopenthixol should be dosed or substituted based on your CYP2D6 phenotype.
| Phenotype | What it means | Recommendation | Evidence |
|---|---|---|---|
| Ultrarapid MetabolizerCYP2D6 | Your body clears this drug faster than usual, so it may not work as well. If it doesn't, your doctor may raise the dose or try a different drug. | DPWG Insufficient data to make a firm dosage recommendation. If effectiveness is insufficient, try a dose increase, but do not exceed 1.5 times the normal dose. Alternatively, consider an antipsychotic that is not metabolised (or to a lesser extent) by CYP2D6 (e.g., flupentixol, quetiapine, olanzapine, clozapine). |
Moderate |
| Normal MetabolizerCYP2D6 | Your CYP2D6 gene works normally, so the usual dose of this drug applies. | DPWG Use standard zuclopenthixol dosing. |
Moderate |
| Intermediate MetabolizerCYP2D6 | Your body clears this drug more slowly, so side effects are more likely. Taking 75% of the usual dose is advised. | DPWG Use 75% of the normal dose. |
Moderate |
| Poor MetabolizerCYP2D6 | Your body clears this drug slowly, so it builds up in your blood. Half the usual dose is advised. | DPWG Use 50% of the normal dose. |
Moderate |
| IndeterminateCYP2D6 | We couldn't read your CYP2D6 result, so we can't say how this gene affects this drug for you. | DPWG Use standard zuclopenthixol dosing and monitor response. |
Not rated |
| Not availableCYP2D6 | We do not have a CYP2D6 result for you, so we cannot personalize guidance for zuclopenthixol. | DPWG Use standard zuclopenthixol dosing and monitor response. |
Not rated |
Source: DPWG
The gene behind the guidance
CYP2D6 Cytochrome P450 2D6
CYP2D6 is the most clinically important pharmacogene. It metabolizes around a quarter of all prescription drugs, including many antidepressants, opioids, and stimulants. The gene is unusually variable: roughly 7 percent of people are poor metabolizers (they barely activate CYP2D6), and another 1 to 3 percent are ultrarapid metabolizers (their enzyme is overactive).
The v4 report preserves the activity score used in its interpretation. Some medicines use a combined CYP2D6/CYP2C19 recommendation. CYP2D6 inhibitors can change functional metabolism; a genotype alone does not capture that effect.
See all drugs affected by CYP2D6Browse the full drug class: Antipsychotics.
Related medications
Find out how your genetics affect Clopixol
Informational only, not medical advice. Pharmacogenetic guidance describes population-level patterns; your individual response depends on many factors. Never start, stop, or change a medication without talking to your prescribing clinician.